Creation and detection of hardware trojans using non-invasive off-the-shelf technologies

As a result of the globalisation of the semiconductor design and fabrication processes, integrated circuits are becoming increasingly vulnerable to malicious attacks. The most concerning threats are hardware trojans. A hardware trojan is a malicious inclusion or alteration to the existing design of an integrated circuit, with the possible effects ranging from leakage of sensitive information to the complete destruction of the integrated circuit itself. While the majority of existing detection schemes focus on test-time, they all require expensive methodologies to detect hardware trojans. Off-the-shelf approaches have often been overlooked due to limited hardware resources and detection accuracy. With the advances in technologies and the democratisation of open-source hardware, however, these tools enable the detection of hardware trojans at reduced costs during or after production. In this manuscript, a hardware trojan is created and emulated on a consumer FPGA board. The experiments to detect the trojan in a dormant and active state are made using off-the-shelf technologies taking advantage of different techniques such as Power Analysis Reports, Side Channel Analysis and Thermal Measurements. Furthermore, multiple attempts to detect the trojan are demonstrated and benchmarked. Our simulations result in a state-of-the-art methodology to accurately detect the trojan in both dormant and active states using off-the-shelf hardware

Treasure Ballybrannigan beach

The main aim of the project was to raise an awareness of the problems that Ballybranigan beach was facing in terms of the erosion damage that had been caused by the sea, and it was thought that if we could gather enough information about the beach, the extended area and how it is still used by the local people and tourists, that the council would be more easily convinced to make the necessary repairs. Approximately 3 months into the placement we were made aware that the council agreed to begin the repair work in the summer to have the beach re-opened. The placement began on 5th December 2017 after a meeting between ourselves, Dr. Malgorzata D’Aughton of UCC School of History, William O’Halloran and Martin Galvin from the CARL Initiative and Kevin Terry and Sean Fitzgerald from the Ballybrannigan community. Dr. D’ Aughton was our supervisor for this placement, and we also kept in constant contact with William from CARL and Kevin and Sean as well whenever we needed guidance on a particular matter. Beginning in December 2017 and ending in May 2018 our work on this project lasted approximately 6 months. It was never concentrated in one particular area, as we were not working in an institution or an office every day, rather we were working on the placement from various locations

The manuscripts of the works of Gerald of Wales

My dissertation is a palaeographical study of the manuscripts of the works of Gerald of Wales (c. 1146-1223). Gerald was a churchman, a member of the court of King Henry II and a prolific author. His extensive works include historical and topographical descriptions of Ireland and Wales, theological and hagiographical studies, and several autobiographical works. Throughout his career he constantly revised these works. A hundred manuscripts containing works of Gerald survive today, and the progress of his revision of his works may be observed from the manuscript-record. I therefore devote some space to the textual history of Gerald's works in the manuscripts; however, the emphasis is on the manuscripts and therefore on what the textual history can show about them, not on the texts themselves. There is an unusually large number of manuscripts (about 20%) surviving from Gerald's lifetime, including some which are decorated and illustrated and at least one which has been described as a 'working copy'. I have studied these manuscripts closely, concentrating on finding similarities between them - particularly the appearance of the same hand in different manuscripts - which may point to a common place of production, possibly 'Gerald's scriptorium'. I have also considered the manuscript evidence for Gerald's publishing processes and the possibility of finding Gerald's autograph. I have then considered the manuscripts surviving from after Gerald's death and what they can show about the continuing tradition of his works, for example: who read them, and which were most popular; the geographical spread of the manuscript-evidence; whether different works were popular at different times, and why; the treatment of the works by later scholars, for example translation, abbreviation and excerpting. This includes evidence which I have discovered for the existence of now lost manuscripts. Finally, I have compared the manuscript-tradition of Gerald's works with that of some other twelfth-century Insular writers whose works survive in various authorial editions and/or in autograph or quasi-autograph copies.This Ph.D. was supported in the flrst nine months by a Walker Research Studentship from Queens' College, and in the following two years and three months by a Postgraduate Award from the AHRB. I have also beneflted from grants from Queens' College, the Jebb Fund and the Faculty of Histoi)' Prince Consort and Thirlwall Fund

Adenoviral Infections in Hematopoietic Stem Cell Transplantation

AbstractAdenoviruses are lytic DNA viruses that are ubiquitous in human communities. In total, 51 different serotypes with varying tissue tropisms have been identified. Adenovirus infections, although frequent, are rarely fatal in immunocompetent individuals who have potent innate and adaptive immunity. But in immunosuppressed individuals, adenoviruses are a significant cause of morbidity and mortality, with limited treatment options. In particular, pediatric recipients of allogeneic hematopoietic stem cell transplantation frequently develop infections early in the posttransplantation period. Because the endogenous recovery of adenovirus-specific T cells has proven important in controlling infection, we explore the potential of adoptive T-cell immunotherapy as a therapeutic strategy. We discuss the advantages and limitations of T-cell therapy for the prophylaxis and treatment of adenovirus infection posttransplantation

Personal non-commercial use only

ABSTRACT. Objective. To prospectively compare clinical examination of the ankle structures with ultrasound (US) findings. Methods. In 42 children with juvenile idiopathic arthritis (JIA; 25 girls, 17 boys, mean age 11.3 yrs, range 2.3-22.3 yrs), a total of 61 swollen/painful ankles were assessed clinically and ultrasonographically. Accurate clinical examination of the entire ankle joint was performed, focusing especially on 3 regions -tibiotalar joint and medial and lateral tendons. Clinical and US findings were both scored 0-3 (normal-severe). Results. US demonstrated no signs of tibiotalar joint effusion in 14 out of 43 ankles considered clinically involved. For the medial tendons, US showed tenosynovitis in 13 ankles out of 31 thought to be clinically normal; and for the lateral tendons, of the 19 deemed to be clinically involved, less than 50% had involvement on US. Very poor agreement was observed comparing the clinical and US scores for the 3 regions: tibiotalar joint, kappa = 0.3; medial tendons, kappa = 0.24; lateral tendons, kappa = 0.25. With regard to other ankle structures, only 39% of the subtalar (talocalcaneal) joints considered clinically involved were deemed abnormal on US. Finally, of the 10 ankles with talonavicular US effusion, only 2 were considered clinically involved

Developing Data Literacy for Data Enabled Student Success

Tapping in to the potential benefits of learning analytics requires staff and students in higher education to be proficient in data literacy. This poster reports on a project to review and identify professional development needs for learning analytics, with an emphasis on the effective use of learning data to promote student success. We report on the development of an evidence based strategy and implementation plan that addresses the skills gaps and professional development requirements of students and higher education staff who teach or lead teaching and learning enhancement. The outputs will enable upskilling of staff and also facilitate students to be more aware, and make greater use of, their own data ‘footprint’. This facilitates the development of important life skills such as self-regulation and self actualisation. In the broader institutional context, this should have the resulting impact of more widespread adoption of evidence based decisions that support student success initiatives

Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease

Introduction: Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease of childhood with a prevalence of around 1 in 1,000. Without appropriate treatment it can have devastating consequences including permanent disability from joint destruction and growth deformities. Disease aetiology remains unknown. Investigation of disease pathology at the level of the synovial membrane is required if we want to begin to understand the disease at the molecular and biochemical level. The synovial membrane proteome from early disease-stage, treatment naive JIA patients was compared between polyarticular and oligoarticular subgroups. Methods: Protein was extracted from 15 newly diagnosed, treatment naive JIA synovial membrane biopsies and separated by two dimensional fluorescent difference in-gel electrophoresis. Proteins displaying a two-fold or greater change in expression levels between the two subgroups were identified by matrix assisted laser desorption ionization-time of flight mass spectrometry with expression further verified by Western blotting and immunohistochemistry. Results: Analysis of variance analysis (P ≤ 0.05) revealed 25 protein spots with a two-fold or greater difference in expression levels between polyarticular and oligoarticular patients. Hierarchical cluster analysis with Pearson ranked correlation revealed two distinctive clusters of proteins. Some of the proteins that were differentially expressed included: integrin alpha 2b (P = 0.04); fibrinogen D fragment (P = 0.005); collagen type VI (P = 0.03); fibrinogen gamma chain (P = 0.05) and peroxiredoxin 2 (P = 0.02). The identified proteins are involved in a number of different processes including platelet activation and the coagulation system. Conclusions: The data indicate distinct synovial membrane proteome profiles between JIA subgroups at an early stage in the disease process. The identified proteins also provide insight into differentially perturbed pathways which could influence pathological events at the joint level

Ex Vivo Expanded Multi-Specific Cytotoxic T Lymphocytes Derived from HIV+ Patients and HIV Negative Donors Using GMP Compliant Methodologies Recognize Multiple HIV Antigens and Suppress HIV Replication

Coderch de Sentmenat, José Antoni